tetrahydrofuran toxicity

12.1 Toxicity Toxicity to fish Toxicity to daphnia and other aquatic invertebrates Toxicity to algae LC50 - Pimephales promelas (fa thead minnow) - 2.160 mg/l - 96 h EC50 - Daphnia magna (W ater flea) - 382 mg/l - 24 h Growth inhibition IC50 - Algae - 3.700 mg/l - 192 h Page 6 of 8 Permissible Daily Exposure (PDE) for Tetrahydrofuran (THF): revision of PDE based on new toxicological data. DISPOSAL CONSIDERATIONS tetrahydrofuran by inhalation, 6 hours per day, 5 days per week, for 14 weeks. Tetrahydrofuran shows low to moderate acute toxicity potential in animals; however, inhalation of tetrahydrofuran vapors affects the central nervous system of human beings, which can result in headache, dizziness, and fatigue [5–8]. Target organs in humans appear to be the central nervous system (CNS), respiratory tract, liver, and kidney. REED. Viridisol ® M has been demonstrated to increase process yields in certain chemical reactions, particularly Grignard Chemistry. Poly(tetrahydrofuran) Toxicity Data With Reference. Tetrahydrofuran _____ ALFAAL13304 SAFETY DATA SHEET Page 6 / 10 Revision Date 07-Jan-2021 Component log Pow Tetrahydrofuran 0.45 2,6-Di-tert-butyl-p-cresol 4.17 Molecular Formula C4 H8 O Molecular Weight 72.11 SECTION 10. 1. orl-rat LD:>10 g/kg : TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Tetrahydrofuran (THF) is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Monomer conversions were lower in the polymerization of both BDO and ODO with diethyl-2,5-furandicarboxylate compared to with dimethyl adipate. THF(tetrahydrofuran) has good solubility to many organic compounds. Tetrahydrofuran can affect you when breathed in and by passing through your skin. Acute toxicity, Oral (Category 5) Skin irritation (Category 3) Eye irritation (Category 2A) Carcinogenicity (Category 2) Specific target organ toxicity - single exposure (Category 3), Respiratory system ... Tetrahydrofuran 109-99-9 TWA 50 ppm USA. Acute toxicity : Not classified Tetrahydrofuran (109-99-9) LD50 oral rat 1650 mg/kg LC50 inhalation rat (ppm) 21000 ppm (Exposure time: 3 h) ATE US (oral) 1650.000 mg/kg body weight Skin corrosion/irritation : Causes severe skin burns and eye damage. Volume pricing available for multiple samples. Ⅰ Chemical formula and molecular weight Chemical formula:C 4 H 8 O Molecular weight: 72.11 CAS No. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000) Tetrahydrofuran 109-99-9 STEL : Short Tetrahydrofuran Results in the Carcinogenic Potency Database. Other compendial tests such as PhEur/PharmEuropa, JP/JPE, AOAC, DAB, and ACS methods are available on request. ... where no macrophage toxicity was exhibited. Target organs in humans appear to be the central nervous system (CNS), respiratory tract, liver, and kidney. 14 (1975),145. The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the following chemicals as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986: Tetrahydrofuran, 2-Ethylhexyl acrylate, Methyl acrylate, Trimethylolpropane triacrylate. THF is one of the most polar ethers. TRANSPORTATION INFORMATION This product is a regulated material for domestic ground transporation, per CFR Title 49. ... reproductive toxicity study ..... 5-5 Table 5-3. Tetrahydrofuran is a colorless liquid with an ether-like odor. Vapor Generation/Exposure System:Tetrahydrofuran vapor was generated with a rotary evaporation system (Buchi Rotavapor, Model EL-131S, Buchi Laboratories Technik AG, Flavil, Switzerland). The vapor entered a short distribution manifold from which individual delivery lines carried metered amounts of the vapor to each exposure chamber. High concentrations in the air may cause narcosis. Tetrahydrofuran (THF, tetramethylene oxide, diethylene oxide, 1,4-epoxybutane, tetrahydrofurane, oxolane) is an industrial solvent widely recognized for its unique combination of useful properties. It is used as an important industrial solvent recognized for its unique combination of useful properties. Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH2)4O. It is very volatile, flammable and only partially soluble in water. Industrial Chemicals Associated with Toxic Hepatitis. The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. B. Section 15: Other Regulatory Information Federal and State Regulations: Connecticut hazardous material survey. All female mice survived until the end of the study. This revision is made due to additional toxicity data have become available for anhydrolinalool oxide (5) [FL-no: 13.097]. (2002). CAP size matters: Tetrahydrofuran amino acid (TAA)-containing linear dodecameric cationic antimicrobial peptides (CAPs) displayed modest antimicrobial activities.However, they were more toxic than their octameric congeners, which had by far the best activity against Mycobacterium tuberculosis with very negligible toxicity, thus implying that the biological activities of this class of … Carbon dioxide and carbon monoxide may form when heated to decomposition. Tetrahydrofuran Market Size Report 2021 by Segmentation includes Type, Applications, Channel and Forecast to 2030 Darlene Dooley — June 16, 2021 9:25 am add comment In a recent published report, Kenneth Research has updated the market report for Tetrahydrofuran … A report on the prechhronic test of tetrahydrofuran using Fischer Rats. LD50 rat (oral): 1,650 mg/kg LC50 rat (by inhalation): > 14.7 mg/l 6 h Tetrahydrofuran (THF) is known to induce the biodegradation of 1,4-dioxane (dioxane), an emerging contaminant, but the mechanisms by which THF affects dioxane biodegradation in microbial communities are not well understood. COMPOSITION NAME: CAS # % BY WEIGHT Tetrahydrofuran 109-99-9 100% Toxicological Data on Ingredients: Tetrahydrofuran: ORAL (LD50): Acute: 1650 mg/kg [Rat]. VAPOR (LC50): Acute: 21000 mg/m 3 hours [Rat]. 4. FIRST AID MEASURES Eye Contact: Check for and remove any contact lenses. Handbook of Environmental Data of Organic Chemicals 2nd … 12.1 Toxicity Toxicity to fish Toxicity to daphnia and other aquatic invertebrates Toxicity to algae LC50 - Pimephales promelas (fa thead minnow) - 2.160 mg/l - 96 h EC50 - Daphnia magna (W ater flea) - 382 mg/l - 24 h Growth inhibition IC50 - Algae - 3.700 mg/l - 192 h Page 6 of 8 The chemically related compound, tetrahydrofuran, is, however, completely miscible with paraffin and water in all proportions, and it has not been reported to be toxic. A 5% solution of … Hazardous Polymerization: May occur. Tetrahydrofuran is a colorless liquid with an ether-like odor. Tetrahydrofuran cas#:(109-99-9) [90-100%] Information on ecological effects Toxicity: Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 2,160 mg/l - 96 h. Toxicity to daphnia EC50 - Daphnia magna (Water flea) - 382 mg/l - 24 h. and other aquatic invertebrates Toxicity to algae Growth inhibition IC50 - Algae - 3,700 mg/l - 192 h. Dimethoxyethane (DME) is a colorless liquid that may be We present in this paper a review of the toxicological and environmental hazards, exposures and risks of tetrahydrofuran (THF; CASRN 109-99-9). Tetrahydrofuran Unknown: 2020 CDR TSCA Inv Active Furan, tetrahydro- Unknown: Active CAA112(b) HON Tetrahydrofuran Valid: RCRA U Waste Tetrahydrofuran Valid: 11/25/1980: Active CAA 111 Tetrahydrofuran Valid: SARA 110 Tetrahydrofuran Valid: 10/20/1988 Tetrahydrofuran shows low to moderate acute toxicity potential in animals; however, inhalation of tetrahydrofuran vapors affects the central nervous system of human beings, which can result in headache, dizziness, and fatigue [5,6,7,8]. 6 Tetrahydrofuran, NTP TR 475 . It is irritating to the skin, mucous membranes and the eyes. EC Inventory: Listed. It is a colorless, volatile cycloaliphatic (5-membered) ether with a characteristic odor; boiling point at 66 C; soluble in water and organic solvents. Deuterated tetrahydrofuran ( d 8 -THF ), is a colourless, organic liquid at standard temperature and pressure. Consult with a doctor. A meta description is an HTML tag in the HTML code of your website, which allows you to customize a section of text that describes the page itself. It can be used to reduce carboxylic acids to alcohols or nitriles to primary amines. Poly(tetrahydrofuran) Toxicity Data With Reference. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = 1.35 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 86.99 (Adapted Stein & Brown method) Melting Pt (deg C): -76.22 (Mean or Weighted MP) VP(mm Hg,25 deg C): 104 (Mean VP of Antoine & … The simplest furan compound is furan itself; a clear, volatile and mildly toxic liquid; melts at -86 C, boils at 32 C, insoluble in water, soluble in alcohol and ether. Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata. In the absence of inhibitors, it may form peroxides and and accumulate peroxides which may explode when subjected to heat or shock. If irritation or symptoms occur, consult with a doctor. :109-99-9 . The substances were evaluated through a stepwise approach that … The compound is classified as heterocyclic compound, specifically a cyclic ether. This revision is made due to additional toxicity data have become available for anhydrolinalool oxide (5) [FL-no: 13.097]. Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Tetrahydrofuran can affect you when breathed in and by passing through your skin. Sprague-Dawley rats and Swiss (CD-1) mice were exposed to 0, 600, 1800, or 5000 ppm THF (a four-carbon cyclic ether, widely used as an industrial solv Acute (short-term) inhalation exposure to tetrahydrofuran … A 5% solution of … STABILITY AND REACTIVITY Stability May form explosive peroxides. It is mainly used as a replacement for Tetrahydrofuran (THF) in specialized applications for its better performance, such as to obtain higher reaction temperatures, or easier separations (as, unlike THF, it is not miscible with water). This Iodine⁄Water⁄Pyridine⁄Tetrahydrofuran (oxidizer) solution comes in a convenient large volume for ABI 394 Nucleic Acid synthesizers, resulting in extended hands-free DNA synthesis. NIOSH: Pocket Guide to Chemical Hazards Tetrahydrofuran 109-99-9 PEL : Permissi ble exposure limit 590 mg/m3 (200 ppm) 02 2006 OSHA_TRANS:US. Parental toxicity was seen at 9000 ppm in the form of reduced water and food intake and body weight gain in both sexes and generations, and increased kidney weights (without a morphologic correlate) in F0 males. Very high exposure can cause unconsciousness and death. J Nat Prod . The tetrahydrofuran containing acetogenins (THF-ACGs) are a naturally occurring class of compounds with potent toxicity against a broad range of tumors, including multidrug resistant (MDR) strains. Tetrahydrofuran Results in the Carcinogenic Potency Database. Tetrahydrofuran 109-99-9 STEL : Short term exposure limit 735 mg/m3 (250 ppm) 2005 NIOSH/GUIDE :US. References. The present consideration concerns a group of 10 tetrahydrofuran derivatives and one furanone derivative evaluated by the JECFA at the 63rd meeting in 2004. Bovine dentin … Hellwig, J., C. Gembardt, S. Jasti. * Breathing Tetrahydrofuran can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. The final mean Tetrahydrofuran (THF) is an organic solvent with excellent solvent power for numerous organic substances, and employed for the extraction of compounds from vegetables, including commercially important compounds such as carotenoids [52,53]. Chemsrc provides Poly(tetrahydrofuran)(CAS#:25190-06-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. :109-99-9 . United States Toxic Substances Control Act (TSCA) Inventory: Listed. Ⅱ Properties and uses THF(tetrahydrofuran)has the characteristics like: low toxic, low boiling point and good liquidity, etc. In this study, an enrichment culture, H-1, with a stable THF-degrading ability and microbial community structure was enriched from activated sludge and could efficiently degrade 95% of 40 mM … It reacts with olefins to add the BH 2 functional group. Acute (short-term) inhalation exposure to tetrahydrofuran … Critical non-cancer endpoints associated with exposure to tetrahydrofuran are central nervous system (CNS) toxicity, increased liver weight and cytomegaly, and developmental toxicity. Tetrahydrofuran had no adverse effect on fertility or reproduction at any dose in this study. Which Plastics Are Toxic? Virtually nontoxic after a single skin contact. Tetrahydrofuran-Health Hazard and Toxicity May 06 2021. THF(tetrahydrofuran) is an important organic synthesis raw material and a good solution. 3. 14 (1975),145. Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Tetrahydrofuran 1650 mg/kg ( Rat ) > 2000 mg/kg (Rabbit) 180 mg/L ( Rat ) 1 h 53.9 mg/L ( Rat ) 4 h Toxicologically Synergistic Products No information available While all seven types of plastic have a degree of toxicity, some are far more toxic than others. Screening for pure or mixed-culture microorganisms that can efficiently degrade THF is difficult due to its chemical stability. Comparative toxicity of C 60 aggregates towards mammalian cells: role of the tetrahydrofuran (THF) decomposition Michael Kovochich , 1, ‡ Benjamin Espinasse , 2, ‡ Melanie Auffan , 2, ‡ Ernest M. Hotze , 2, ‡ Lauren Wessel , 2 Tian Xia , 1 Andre E. Nel , 1, 3, 4 and Mark R. Wiesner 1, * Sci ... 82 chemical development as an alternative to its more common analogues such as tetrahydrofuran Objectives The aim of this study was to investigate the cytotoxicity and 1-year dentin bond stability of solvated etch-and-rinse dental adhesives based on tetrahydrofuran (THF), acetone, or ethanol, containing water or not. In addition, THF shows low toxicity, and is known as a renewable solvent which can be produced from bio-derived chemicals. 1. Borane–tetrahydrofuran (BH 3 –THF) is a charge-transfer complex that is a useful surrogate for diborane 1 in organic synthesis. The product is a tetrahydrofuran (THF) solution containing 20%(v/v) 1,2-propanediol. Dibasic esters (DBE) are by-products from the synthesis of adipic acid that are a less volatile and safer alternative to methylene chloride. Tetrahydrozoline is a form of a medicine called imidazoline, which is found in over-the-counter eye drops and nasal sprays. PubMed: The 3-(N-tert-butylcarboxamido)-1-propyl group as an attractive phosphate/thiophosphate protecting group for solid-phase oligodeoxyribonucleotide synthesis. The site is secure. Tetrahydrofuran (THF) is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Herein, this review concentrates on the advances of H2O/THF system in lignocellulose valorization in recent years. 72 toxicity and teratogenicity of three potential biofuels also used as flavor or solvent. As one of the most polar ethers with a wide liquid range, it is a useful solvent. Domestic producers and distributors of THF are identified, and the production processes involving furfural (98011), acetylene (74862), and formaldehyde (50000) are described. Revision: 07/13/2017 Page: 2 of 5 para-fluoro Tetrahydrofuran fentanyl (hydrochloride) SAFETY DATA SHEET 2.3 Harmful if inhaled, swallowed, or in contact with skin. Handbook of Environmental Data of Organic Chemicals 2nd ed LC50 Rat inhalation 62,000 ppm/2 hr . The compound is heterocyclic. Hejtmanik, M. (1983a). Tetrahydrofuran agent detailed information in Haz-Map database. Tetrahydrofuran (THF) is an organic compound with the formula (CH 2) 4 O. 13. Tetrahydrofuran, reagent grade, was purchased from the Matheson Coleman and Bell Division, the Matheson Co., Norwood, Ohio. Symptoms of CNS toxicity included headache, dizziness, fatigue, and loss of sense of smell. Ⅰ Chemical formula and molecular weight Chemical formula:C 4 H 8 O Molecular weight: 72.11 CAS No. demonstrated that tetrahydrofuran exhibits adverse acute toxicity Serious eye damage/irritation : Causes serious eye damage. It acts as an industrial solvent for making polyvinyl chloride (PVC), the plastic that the majority of indoor plumbing is made out of, and it also dissolves PVC, and therefore is a primary ingredient in PVC adhesives. Acute toxicity : Not classified Tetrahydrofuran (109-99-9) LD50 oral rat 1650 mg/kg LC50 inhalation rat (ppm) 21000 ppm (Exposure time: 3 h) ATE US (oral) 1650.000 mg/kg body weight Skin corrosion/irritation : Causes severe skin burns and eye damage. Being polar and having a wide liquid range, THF is a versatile solvent. A chronic RfD for THF has been derived from the oral drinking water 2-generation reproductive toxicity study (BASF, 1996; Hellwig et al., 2002) in rats. It plays a role in how your page is seen by search engine crawlers, and how it appears in SERPs Incompatibilities: Tetrahydrofuran reacts violently with air on standing. This invention relates to a novel method for the preparation of 3-oxo-tetrahydrofuran comprising oxidizing 3-hydroxy-tetrahydrofuran in the presence of a catalytic amount of 2,2,6,6-tetramethyl-piperidine-N-oxyl (TEMPO) with trichloroisocyanuric acid. It is also used in PVC reactor cleaning and PVC film casting. China Catalog of Hazardous chemicals 2015: Listed. THF is a polar solvent and monomer that is easily absorbed by all routes of exposure. Handle toxic compressed gases in Flammable Compressed Gases Release of Toxic Gas a chemical fume hood Oxidizing Compressed Gases Hydrogen Sulfide is a colorless, Indoor storage or use of toxic compressed gases shall be provided with a gas cabinet, exhausted enclosure, or gas room flammable, extremely hazardous Symptoms of CNS toxicity included headache, dizziness, fatigue, and loss of sense of smell. THF, a saturated cyclic ester, is a water miscible organic solvent. PS is also considered to be a highly toxic form of plastic. The formation of aqueous two-phase explored combined with tetrahydrofuran. The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The data in review was the information published Tetrahydrofuran 109-99-9 Ecotoxicity (aquatic and terrestrial, where available): Acute algae toxicity (TETRAHYDROFURAN) Growth inhibition NOEC / 192h / Algae - 3700 mg/l Acute fish toxicity (TETRAHYDROFURAN) LC50 / 96h / Fathead minnow - 2160 mg/l Persistence and degradability: Biodegradation is expected. Our database provides you with basic information on more than 1,500 hazardous substances and guides you, according to a substance, to suitable gas detectors and protection equipment. Toxicity: SKN-RBT LD50 4500 mg kg-1 OU Chemical Safety Data (No longer updated) More details: Safety: 11/19/2013 12:00:00 AM Alfa Aesar L07356: 11-19 Alfa Aesar L07356: 19-Nov Alfa Aesar L07356: 20/21/22 Novochemy [NC-19856] 20/21/36/37/39 Novochemy [NC-19856] Acute Toxicity Product Information No acute toxicity information is available for this product Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Tetrahydrofuran 1650 mg/kg ( Rat ) > 2000 mg/kg (Rabbit) 180 mg/L ( Rat ) 1 h 53.9 mg/L ( Rat ) 4 h 2,6-Di-tert-butyl-p-cresol >2000 mg/kg ( Rat ) >2000 mg/kg ( Rat ) Not listed Synonym: Tetrahydrofuran stabilized with … Tetrahydrofuran: Tetrahydrofuran: 109-99-9: none: European Inventory of Existing Commercial Chemical Substances (EINECS) Listed. Other articles where Tetrahydrofuran is discussed: ether: Complexes of ethers with reagents: …as its liquid complex with tetrahydrofuran (THF). : Tetrahydrofuran Illinois toxic substances disclosure to employee act: Tetrahydrofuran It is very volatile, flammable and only partially soluble in water. The substance can be absorbed through the skin. Repeated exposures to THF in laboratory animals has produced mainly transitory narcosis and mild adaptive responses – respiratory and mucous membrane irritation, COMPOSITION COMPOSITION NAME: CAS # % BY WEIGHT Tetrahydrofuran 109-99-9 100% Apertus offers residual solvents testing per USP-NF 467 guidelines. It's characterized as … Materials and methods Seven primers were prepared using the following solvents: THF, acetone, ethanol, water, THF/water, acetone/water, and ethanol/water. IRIS assessment development process. Repeated or prolonged exposure to the substance can produce target organs damage. An example is a worker who becomes ill with toxic hepatitis after using one of the solvents in a … Identification: : Tetrahydrofuran UNNA: 2056 PG: Il Special Provisions for Transport: Not available. Product Name Tetrahydrofuran Page 9 of 13 (ECHA) Symptoms: Irritation of mucous membrances Acute Inhalation toxicity Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract Acute Dermal toxicity No Data Available Skin corrosion/irritation * 2-Methyl Tetrahydrofuran is a HIGHLY FLAMMABLE LIQUID and a DANGEROUS FIRE HAZARD. Toxicity studies have demonstrated Viridisol ® M (2-MeTHF) to possess low genotoxicity. H302 H armful if swallowed. It is mainly used as a precursor to polymers. Benzotrifluoride (BTF, C7H5F3) is a less toxic and more environmentally friendly alternative to tetrahydrofuran and methylene chloride. Eye contact: Wash eyes for at least 15 minutes with plenty of water. The combustion studies of THF have been reported. Tetrahydrofuran: two-generation reproduction toxicity in Toxicology of New Industrial Chemical Sciences. Tetrahydrofuran (THF, tetramethylene oxide, diethylene oxide, 1,4-epoxybutane, tetrahydrofurane, oxolane) is an industrial solvent widely recognized for its unique combination of useful properties. New use in P-series fuels is increasing market demand Virtually no information on toxicity; concerns about possibility that methyl tetrahydrofuran Toxicology of New Industrial Chemical Sciences. Toxicity of γ-butyrolactone (72-hr lethal concentration predicted to kill 50% was 47 ppm) indicated effects in THF treatments can result from γ-butyrolactone toxicity. It is a colorless, water-miscible organic liquid with low viscosity. In rats the LC50 (4hr) is 53.9 mg/l (18,271 ppm). Please comment on whether the selection of this study as … 1. orl-rat LD:>10 g/kg : TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Prolonged storage in contact with air and in the absence of an antioxidant may cause THF to decompose into explosive peroxides. Ⅱ Properties and uses THF(tetrahydrofuran)has the characteristics like: low toxic, low boiling point and good liquidity, etc. Hygroscopic. PubMed:Tetrahydrofuran: two-generation reproduction toxicity in Wistar rats by continuous administration in the drinking water. Tetrahydrofuran (THF) is a widely used industrial solvent and was selected for carcinogenesis studies by the National Toxicology Program (NTP) because of its potential for widespread occupational exposure in humans and a lack of information on animal toxicity and carcinogenicity. According to the harmonised classification and labelling (ATP03) approved by the European Union, this substance is a highly flammable liquid and vapour, causes serious eye irritation, is suspected of causing cancer and may cause respiratory irritation. H360 (12.44%): May damage fertility or the unborn child [Danger Reproductive toxicity] H412 (18.91%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] It is a highly flammable, mobile liquid. Especially if they have screw caps, these should not be opened but should be disposed of by the appropriate authorities. SAFETY DATA SHEET: TETRAHYDROFURAN 1. IDENTIFICATION PRODUCT NAME: TETRAHYDROFURAN CAS #: 109-99-9 SYNONYM: THF 2. HAZARDS IDENTIFICATION Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant). Slightly hazardous in case of skin contact (permeator), of ingestion, of inhalation. Tetrahydrofuran; CASRN 109-99-9. * Tetrahydrofuran can cause headache, nausea and dizziness. The chemicals in this list are known to cause illness or death due to acute hepatic injury after occupational exposure. However, the equally high toxicity to normal cells presents a hurdle for their clinical advancement. Comparative toxicity of C 60 aggregates towards mammalian cells: role of the tetrahydrofuran (THF) decomposition Michael Kovochich , 1, ‡ Benjamin Espinasse , 2, ‡ Melanie Auffan , 2, ‡ Ernest M. Hotze , 2, ‡ Lauren Wessel , 2 Tian Xia , 1 Andre E. Nel , 1, 3, 4 and Mark R. Wiesner 1, * Toxicity Data: Tetrahydrofuran LD50 (oral, guinea pig) 2300 mg/kg LC50 (inhalation, rat) 21000 ppm/3hr 14. PVC is the most hazardous plastic and has been dubbed the “poison plastic” because it contains numerous toxins that it can leach throughout its entire life cycle. Tetrahydrofuran 109-99-9 STEL : Short term exposure limit 735 mg/m3 (250 ppm) 2005 NIOSH/GUIDE:US. Synonym: Tetrahydrofuran stabilized with … OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000) Tetrahydrofuran 109-99-9 STEL : Short term July 12, 2016 at 12:20 pm I love doing my own press on nails…so the Kiss glue in any form is cancer causing. High Purity 99.9% Cas 109-99-9 Tetrahydrofuran , Find Complete Details about High Purity 99.9% Cas 109-99-9 Tetrahydrofuran,Tetrahydrofuran,Thf,109-99-9 from Syntheses Material Intermediates Supplier or Manufacturer-Anhui Jin'ao Chemical Co., Ltd. 109-99-9) In Support of Summary Information on the Integrated Risk Information System (IRIS) February 2012 . Approval by the Steering Committee of the new PDE for THF under Step 2 and release for public consultation. Two male mice exposed to 5,000 ppm died during weeks 2 and 8 of the study; one male mouse from the 5,000 ppm group was killed in a moribund state during week 4. 20 July 2000 Q3C(R1) Note: Prior to adding the revision to the parent Guideline in November 2005, the code was Q3C(M) for THF. 2. orl-mus LD:>10 g/kg However, the revised IDLH is 2,000 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 2%). DEVELOPMENTAL TOXICITY: Not available. (B) Oral Reference Dose (RfD) For Tetrahydrofuran 1. Other articles where Tetrahydrofuran is discussed: ether: Complexes of ethers with reagents: …as its liquid complex with tetrahydrofuran (THF). Dahme and Rothemund recommended its use after a search for a non-toxic reagent miscible with both water and molten paraffin wax. Gulf South Research Institute . Interestingly, the activity of compound 8 on axenic amastigotes and … The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Deuterated THF is used as a solvent in NMR spectroscopy, though its expense can often be prohibitive. The initial metabolic step in THF metabolism is oxidative metabolism by cytochrome P450 enzymes (CYPs) with further hydrolysis by paraoxonase 1 (PON1) and further action of cytoplasmic dehydrogenases. Tetrahydrofuran (THF) is a widely used industrial solvent and was selected for carcinogenesis studies by the National Toxicology Program (NTP) because of its potential for widespread occupational exposure in humans and a lack of information on animal toxicity and carcinogenicity. 2. Benzotrifluoride (BTF, C7H5F3) is a less toxic and more environmentally friendly alternative to tetrahydrofuran and methylene chloride. New Zealand Inventory of Chemicals (NZIoC) Listed. Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry. European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... European Food Safety Authority (EFSA) reference(s): Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the … Tetrahydrofuran-Health Hazard and Toxicity May 06 2021. THF, a saturated cyclic ester, is a water miscible organic solvent. NIOSH: Pocket Guide to Chemical Hazards Tetrahydrofuran 109-99-9 PEL : Permissi ble exposure limit 590 mg/m3 (200 ppm) 02 2006 OSHA_TRANS :US. Tetrahydrofuran (THF) is commonly used as solvent, reaction medium, and starting material for various syntheses in the chemical industry. It will give you a list of non toxic cosmetics by category and you can also look up individual products and it will give you the ingredients and toxicity rating. H331 Toxic if inhaled. A report on the prechronic test of tetrahydrofuran using B6C3F1 mice. Similarly, gaseous boron trifluoride (BF3) is more easily used as its liquid complex with diethyl ether, called BF3 etherate, rather than as the toxic, corrosive gas. The invention discloses a method for separating acetone-tetrahydrofuran mixture through extractive distillation. Prolonged storage in contact with air and in the absence of an antioxidant may cause THF to decompose into explosive peroxides. Environmental: If released to the atmosphere, tetrahydrofuran will exist solely in the vapor phase and is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals with half-lives of about 1 and 3 days, respectively. Groups of 10 rats and mice of each sex were administered THF vapor by whole body inhalation for 13 weeks at exposure concentrations of 0, 66, 200, 600, 1800, and 5000 ppm. The combustion studies of THF have been reported. The substance may be toxic to blood, kidneys, lungs, liver, upper respiratory tract, skin, eyes, central nervous system (CNS). Vapors cause nausea, dizziness, headache, and anesthesia. Liquid can de-fat the skin and cause irritation. Liquid also irritates eyes. (USCG, 1999) Reactivity Profile TETRAHYDROFURAN reacts violently with oxidizing agents leading to fires and explosions [Handling Chemicals Safely 1980. p. 891]. Subject to peroxidation in the air.

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